“It’s hard to kill a city,” West began, “but easy to kill a company.” The mean life of companies is 10 years. Cities routinely survive even nuclear bombs. And “cities are the crucible of civilization.” They are the major source of innovation and wealth creation. Currently they are growing exponentially. “Every week from now until 2050, one million new people are being added to our cities.”

That’s from the intro to Geoffrey West’s Long Now seminar “Why Cities Keep on Growing, Corporations Always Die, and Life Gets Faster”.

Kevin Kelly summarized it in this way:

All organisms (and companies) have share many universal laws of growth. Creatures age in the same way, whether they are small animals, large mammals, starfish, bacteria, and even cells. They share similar metabolic rates. Similar distributions. All ecosystems (and cities) also share universal laws. They evolve and scale in a similar fashion among themselves — whether they are forests, meadows, coral reefs, or grasslands, or villages.

Geoff West from the Santa Fe Institute has piles of data to prove these universal and predictive laws of life. For instance, organisms scale in a 3/4 law. For every doubling in size, they increase in other factors by less than one, or .75. The bigger the organism, the slower it goes. Both elephants and mice have the same number of heartbeats per lifespan, but he elephant beats slower.

Ecosystems and cities, on the other hand, scale by greater than one, or 1.15. Every year cities increase in wealth, crime, traffic, patents, pollution, disease, infrastructure, and per capita by 15%. The bigger the city, the faster it goes.

Geoff’s talk is worth a listen, especially as you consider how companies grow and evolve over timespans measured in decades, not years or rounds of funding.

Your body has about ten times the number of microbial cells as it does human cells. Collectively this bacteria weighs about three pounds, about the same as your brain. The evolution of our understanding of these bacteria has been evolving rapidly over the past twenty years, and I expect its findings to be the most impactful on our health and wellness in the coming decades.

The New Yorker has a fantastic article by Michael Specter that starts and ends with our changing perception of heliobacter pylori, linked to gastritis and peptic ulcers, but whose absence in children (it used to be universal, now fewer than 5% of children in the US carry it in their guts) is linked to asthma. It also has consequences for weight:

There is equally convincing evidence that destroying H. pylori could alter metabolism in ways that increase the risk of obesity. Several research groups, including Blaser’s, have found a strong relationship in humans between the bacterium and two stomach hormones, ghrelin and leptin, both of which play central roles in regulating our appetites […] The more ghrelin you have in your bloodstream, the more likely you are to overeat. Leptin functions in the opposite way, suppressing appetite and increasing energy levels. For people whose stomachs are infected by H. pylori, ghrelin became far less detectable after a meal. For the others, levels of the hormone remained high, and the effects are evident. […]

That finding was not a complete surprise. Roughly three-quarters of the antibiotics consumed in the United States are fed to poultry, cows, and pigs, not to treat illness but as dietary supplements to promote faster growth. […] Until recently, the biochemical reasons for that weight gain, and its unsettling implications or humans, were murky. […] “A lot of things are happening at once,” he said. “The rise in obesity, celiac disease, asthma, allergy syndromes, and Type 1 diabetes. Bad eating habits are not sufficient to explain the world-wide explosion in obesity.

The environment inside our body is as complex and varied as the one outside our body and responds just as unpredictably to wholesale changes to its ecosystem. I’d recommend reading the entire article, unfortunately it’s not available in its entirety on the New Yorker’s site, however here’s a PDF of the entire thing.